Production of [18F]F-DOPA, [18F]FDG, [18F]FLT, [18F]FHBG, [18F]FDDNP, [18F]MISO, [18F]FAZA and [18F]Fluorocholine
The Synthra RNplus Research is a flexible and completely automated radio synthesis system for routine production or research of [18F]fluorine labeled compounds by nucleophilic substitution.
The module offers two reaction vessels in two different sizes, a 5 mL conical shape for 150 µL reaction volumes and one with 11 mL. Synthra’s most versatile module also contains a column oven for heterogeneous reaction steps.
The module provides an integrated, quaternary gradient Radio-HPLC with a variable wavelength detector. The HPLC is equipped with two columns, a switching valve and two fraction collection vials, which allow one in-process and one final purification step by selection of the column.
The whole system is closed. The evacuation is performed via a cooling trap with liquid nitrogen, to trap volatile radioactive substances and to protect the integrated vacuum pump.
The module contains a filter integrity test capability according to GMP. After filtration of the final formulated radiopharmaceutical product, an automated pressure hold test, according to GMP, is performed at the sterile filter. The measuring procedure is monitored and graphically documented.
Examples for [18F] compounds
|FLT||DNA proliferation||Tumor cell proliferation|
|FDDNP||ß-Amyloid protein||Alzheimer disease|
|Flumazenil||Benzodiacepine receptor||Epileptic foci|
|FHBG||Gene expression||Cancer gene therapie|
|Fluorocholine||Choline kinase||Prostate I tumor|
|F-Mizo||Hypoxic cell marker||Head and neck cancer|
|F-Dopa||D2 dopamine receptors||Neurodegenerative diseases|
|FDG||Glucose metabolism||Tumor diagnostic|
Yields, setup time and synthesis time will vary depending on the biomarker produced.
Yields are dependent on use of proper technique and appropriate reagents.
|Dimensions||64 cm x 48 cm x 49 cm (w x d x h)|
|Weight||Approx. 42 Kg|
|Hot Cell (minimum size)||75 cm x 55 cm x 55 cm (w x d x h)|