Synthra RNplus

Production of [18F]F-DOPA, [18F]FDG, [18F]FLT, [18F]FHBG, [18F]FDDNP, [18F]MISO, [18F]FAZA and [18F]Fluorocholine

The Synthra RNplus Research is a flexible and completely automated radio synthesis system for routine production or research of [18F]fluorine labeled compounds by nucleophilic substitution.

The module offers two reaction vessels in two different sizes, a 5 mL conical shape for 150 µL reaction volumes and one with 11 mL. Synthra’s most versatile module also contains a column oven for heterogeneous reaction steps.

The module provides an integrated, quaternary gradient Radio-HPLC with a variable wavelength detector. The HPLC is equipped with two columns, a switching valve and two fraction collection vials, which allow one in-process and one final purification step by selection of the column.

The whole system is closed. The evacuation is performed via a cooling trap with liquid nitrogen, to trap volatile radioactive substances and to protect the integrated vacuum pump.

The module contains a filter integrity test capability according to GMP. After filtration of the final formulated radiopharmaceutical product, an automated pressure hold test, according to GMP, is performed at the sterile filter. The measuring procedure is monitored and graphically documented.

Download detailed specification of RNplus Research radiosynthesizer

Examples for [18F] compounds

[18F]-Radiotracer Target Application
FLT DNA proliferation Tumor cell proliferation
FDDNP ß-Amyloid protein Alzheimer disease
Flumazenil Benzodiacepine receptor Epileptic foci
FHBG Gene expression Cancer gene therapie
Fluorocholine Choline kinase Prostate I tumor
F-Mizo Hypoxic cell marker Head and neck cancer
F-Dopa D2 dopamine receptors Neurodegenerative diseases
FDG Glucose metabolism Tumor diagnostic


Yields, setup time and synthesis time will vary depending on the biomarker produced.

Yields are dependent on use of proper technique and appropriate reagents.

Dimensions 64 cm x 48 cm x 49 cm (w x d x h)
Weight Approx. 42 Kg
Hot Cell (minimum size) 75 cm x 55 cm x 55 cm (w x d x h)