Synthra C-11 Choline

Production of C-11 Choline


A completely automated synthesis system for routine production of C-11 Choline by cartridge separation and purification. Using in-target produced Carbon dioxide, utilizing gas phase [11C]-CH3I reactions, high specific activity preparations of [11C]-CH3I are produced ranging from 15 Ci/┬Ámol to 50 Ci/┬Ámol when high purity target gas is used for [11C]-CO2 production.

On column methylation with CH3I is applied for the generation of C-11 Choline. Further cartridge purification and formulation yields in a fast and reliable production without the use of a Radio-HPLC.

Download detailed specification of C-11 Choline radiosynthesizer

Download detailed specification of C-11 Choline radiosynthesizer AgOTf


Examples for [11C] compounds

[11C]-Radiotracer Target Application
Choline Choline kinase Brain tumors, prostate, lung and esophageal cancer

Specifications:

Yields and specific activity of labelled C-11 tracers are dependent on use of proper technique and appropriate reagents.

Yields >50 % for [11C]-CH3I in less than 8 min
Maximum [11C]-CO2 starting activity 370 GBq
Synthesis time for C-11-Choline 20 min
Yield for C-11 Choline [RCY] 30%
Radiochemical Purity for C-11-Choline >98%
Time for sequential synthesis <10 minutes
Number of consecutive [11C]-CH3I synthesis 15
Dimensions 55 x 48 x 50 cm (w x d x h)
Weight Approx. 40 Kg
Hot Cell (minimum size) 65 x 50 x 50 cm (w x d x h)