Production of 11C labelled tracer by Methyl Iodide or Methyl Triflate gas phase synthesis
A flexible and completely automated synthesis system for routine production of any [11C]-labelled tracer either by applying [11C]-Methyl Iodide or optional / [11C]-Methyl Triflate. Using [11C]-Methyl Iodide from the Synthra MeI synthesizer, heterogeneous labeling reactions in a heated cartridge holder or homogenous reactions in the reaction vessel or as well as conversion to [11C]-Methyl Triflate and further heterogeneous or homogenous preparations are possible from a single box set-up.
Radio-HPLC combined with solid phase extraction (SPE) is applied for the purification of C-11 labelled compounds. After formulation and sterile filtration an automated filter integrity test can be performed.
Examples for electrophilic [11C] compounds
|Raclopride||D2 dopamine receptors||Neuropsychiatric disorders|
|DASP||D2 dopamine receptors||Neuropsychiatric disorders|
|Flumazenil||Benzodiacepine receptor||Neurodegenerative diseases|
|Methionine||Amino acid transporter||Brain, head and neck, lung and breast cancer, lymphomas|
|Choline||Choline kinase||Brain tumors, prostate, lung and esophageal cancer|
|Thymidine||Thymidine kinase-1||Tumor proliferation|
|Palmitate||Myocardinal tissue fatty acid metabolism||Heart diseases|
Yields and specific activity of labelled C-11 tracers are dependent on use of proper technique and appropriate reagents.
|Yields||Depending on the selected tracer|
|Time for sequential synthesis||<50 minutes|
|Dimensions||55 x 48 x 50 cm (w x d x h)|
|Weight||Approx. 45 Kg|
|Hot Cell (minimum size)||65 x 50 x 50 cm (w x d x h)|