Synthra GPextent

Production of 11C labelled tracer by Methyl Iodide or Methyl Triflate gas phase synthesis



A flexible and completely automated synthesis system for routine production of any [11C]-labelled tracer either by applying [11C]-Methyl Iodide or optional / [11C]-Methyl Triflate. Using [11C]-Methyl Iodide from the Synthra MeI synthesizer, heterogeneous labeling reactions in a heated cartridge holder or homogenous reactions in the reaction vessel or as well as conversion to [11C]-Methyl Triflate and further heterogeneous or homogenous preparations are possible from a single box set-up.

Radio-HPLC combined with solid phase extraction (SPE) is applied for the purification of C-11 labelled compounds. After formulation and sterile filtration an automated filter integrity test can be performed.

Download detailed specification of GPextent radiosynthesizer


Examples for electrophilic [11C] compounds

[11C]-Radiotracer Target Application
Raclopride D2 dopamine receptors Neuropsychiatric disorders
DASP D2 dopamine receptors Neuropsychiatric disorders
Flumazenil Benzodiacepine receptor Neurodegenerative diseases
Methionine Amino acid transporter Brain, head and neck, lung and breast cancer, lymphomas
Choline Choline kinase Brain tumors, prostate, lung and esophageal cancer
Thymidine Thymidine kinase-1 Tumor proliferation
Palmitate Myocardinal tissue fatty acid metabolism Heart diseases

Specifications:

Yields and specific activity of labelled C-11 tracers are dependent on use of proper technique and appropriate reagents.

Yields Depending on the selected tracer
Time for sequential synthesis <50 minutes
Dimensions 55 x 48 x 50 cm (w x d x h)
Weight Approx. 45 Kg
Hot Cell (minimum size) 65 x 50 x 50 cm (w x d x h)