Synthra MeIplus Loop Vessel
Production of wide variety of Carbon-11 labeled compounds based on the generation of gas-phase C-11 methyl iodide or optional C-11 methyl triflate synthesis
Synthra MeIplus loop vessel is a flexible and completely automated synthesis system for routine production of wide variety of [11C]carbon-labeled compounds based on the generation of gas-phase [11C]methyl iodide or optional [11C]methyl triflate synthesis. Automating the synthesis is simple, with easy-to-use configuration software SynthraView - the Synthra MeIplus Research module offers both, fully automatic and manual modes of operation.
Using in-target produced carbon dioxide, high specific activity preparations are produced ranging from 10 Ci/μmol to 24 Ci/μmol when high purity target gas is used for [11C]CO2 production.
First the carbon dioxide is trapped in a stainless steel tube at -180 °C and converted to [11C]methane by reduction on a Ni catalyst. The [11C]methane is trapped at -120 °C on a Carbosphere® column and the hydrogen is removed from the system. In a successive gas phase reaction the [11C]methane is converted into [11C]methyl iodide and trapped on Porapak Q in a column. Methyl iodide is ready for release after only 7 min starting from trapping the [11C]carbon dioxide. The yield for the [11C]methyl iodide formation is better than 50% non decay corrected.
Examples for [11C] compounds
|Choline||Choline kinase||Brain tumors, prostate, lung and esophageal cancer|
|DASB||ßSERT receptors||Neuropsychiatric disorders|
|Flumazenil||Benzodiacepine receptor||Neurodegenerative diseases|
|Methionine||Amino acid transporter||Brain, head and neck, lung and breast cancer, lymphomas|
|PHNO||D3 dopamine receptors||Neuropsychiatric disorders|
|Raclopride||>D2 dopamine receptors||Neuropsychiatric disorders|
|Thymidine||Thymidine kinase-1||Tumor proliferation|
Total activity is dependent on the produced [11C]CO2, which means it is dependent on the selected cyclotron. Yields and specific activity of labeled [11C]tracers are dependent on use of proper technique and appropriate reagents.
|Time for sequential synthesis||Depends on the selected synthesis|
|Number of consecutive [11C]CH3I synthesis||15, then exchange of NaOH traps|
|Dimensions||54 x 45 x 48 cm (w x d x h)|
|Weight||Approx. 37 Kg|
|Hot Cell (minimum size)||65 x 55 x 55 cm (w x d x h)|