Synthra MeIplus Loop Vessel

Production of wide variety of Carbon-11 labeled compounds based on the generation of gas-phase C-11 methyl iodide or optional C-11 methyl triflate synthesis


Synthra MeIplus loop vessel is a flexible and completely automated synthesis system for routine production of wide variety of [11C]carbon-labeled compounds based on the generation of gas-phase [11C]methyl iodide or optional [11C]methyl triflate synthesis. Automating the synthesis is simple, with easy-to-use configuration software SynthraView - the Synthra MeIplus Research module offers both, fully automatic and manual modes of operation.

Using in-target produced carbon dioxide, high specific activity preparations are produced ranging from 10 Ci/μmol to 24 Ci/μmol when high purity target gas is used for [11C]CO2 production.

First the carbon dioxide is trapped in a stainless steel tube at -180 °C and converted to [11C]methane by reduction on a Ni catalyst. The [11C]methane is trapped at -120 °C on a Carbosphere® column and the hydrogen is removed from the system. In a successive gas phase reaction the [11C]methane is converted into [11C]methyl iodide and trapped on Porapak Q in a column. Methyl iodide is ready for release after only 7 min starting from trapping the [11C]carbon dioxide. The yield for the [11C]methyl iodide formation is better than 50% non decay corrected.

Download detailed specification of MeIplus Loop Vessel radiosynthesizer


Examples for [11C] compounds

[11C]-Radiotracer Target Application
Choline Choline kinase Brain tumors, prostate, lung and esophageal cancer
DASB ßSERT receptors Neuropsychiatric disorders
Flumazenil Benzodiacepine receptor Neurodegenerative diseases
Methionine Amino acid transporter Brain, head and neck, lung and breast cancer, lymphomas
PHNO D3 dopamine receptors Neuropsychiatric disorders
Raclopride >D2 dopamine receptors Neuropsychiatric disorders
Thymidine Thymidine kinase-1 Tumor proliferation

Specifications:

Total activity is dependent on the produced [11C]CO2, which means it is dependent on the selected cyclotron. Yields and specific activity of labeled [11C]tracers are dependent on use of proper technique and appropriate reagents.

Time for sequential synthesis Depends on the selected synthesis
Number of consecutive [11C]CH3I synthesis 15, then exchange of NaOH traps
Dimensions 54 x 45 x 48 cm (w x d x h)
Weight Approx. 37 Kg
Hot Cell (minimum size) 65 x 55 x 55 cm (w x d x h)