Synthra MeIplus Research
Production of wide variety of Carbon-11 labeled compounds based on the generation of gas-phase C-11 methyl iodide or optional C-11 methyl triflate synthesis
The Synthra MeIplus Research is a flexible and completely automated synthesis system for routine production of any [11C]carbon labeled compound based on the generation of gas-phase [11C]methyl iodide or optional [11C]methyl triflate synthesis or Grignard reactions.
Nine reagent vials with dead volume free connections to the valves enabling multistep radio synthesis procedures. All wetted components are chemically inert, simplifying maintenance and protecting the final product.
The system contains two closed reaction vessels, to enable multistep reactions. Both reaction vessels contain a heating and a cooling function ( 196 °C - 250 °C) to reduce reaction time.
The module provides an integrated, quaternary gradient Radio-HPLC with a variable wavelength detector. The HPLC is equipped with two columns and a switching valve that allows in-process purification steps for different tracer by selection of the column. After HPLC separation a solid phase extraction (SPE) is integrated for a reliable production and formulation of isotonic injectable solutions of [11C]compounds with high specific activity.
The synthesis unit has a built-in detector to determine the activity of the final radiopharmaceutical preparation.
The module also contains a filter integrity test capability according to GMP. After filtration of the final formulated radiopharmaceutical product, an automated pressure hold test, according to GMP, is performed at the sterile filter. The measuring procedure is monitored and graphically documented. The whole system is closed. The evacuation is performed via a cooling trap with liquid nitrogen, to trap volatile radioactive substances and to protect the integrated vacuum pump.
Examples for electrophilic [11C]compounds
|Raclopride||D2 dopamine receptors||Neuropsychiatric disorders|
|DASP||SERT receptors||Neuropsychiatric disorders|
|Flumazenil||Benzodiacepine receptor||Neurodegenerative diseases|
|Methionine||Amino acid transporter||Brain, head and neck, lung and breast cancer, lymphomas|
|Choline||Choline kinase||Brain tumors, prostate, lung and esophageal cancer|
|Thymidine||Thymidine kinase-1||Tumor proliferation|
|Palmitate||Myocardinal tissue fatty acid metabolism||Heart diseases|
Total activity is dependent on the produced [11C]CO2, which means it is dependent on the selected cyclotron. Yields and specific activity of labeled [11C]tracers are dependent on use of proper technique and appropriate reagents.
|Time for sequential synthesis||Depends on the selected synthesis|
|Number of consecutive [11C]CH3I synthesis||15, then exchange of NaOH traps|
|Dimensions||65 x 48 x 48 cm (w x d x h)|
|Weight||Approx. 48 Kg|
|Hot Cell (minimum size)||75 x 55 x 55 cm (w x d x h)|