Synthra MeIplus

Production of carbon-11 labeled compounds based on C-11 methyl iodide or optional C-11 methyl triflate synthesis




A flexible and completely automated synthesis system for routine production of wide variety of carbon-11 labeled compounds based on the generation of gas-phase C-11 methyl iodide or optional C-11 methyl triflate.

The synthesis unit includes all components needed for preparation, labeling, purification and formulation of carbon-11 labeled compounds. Using in-target produced carbon dioxide, high specific activity preparations are produced ranging from 15 Ci/┬Ámol to 50 Ci/┬Ámol when high purity target gas is used for [11C]-CO2 production.

Download detailed specification of MeIplus radiosynthesizer


Examples for electrophilic [11C]compounds

[11C]Radiotracer Target Application
Raclopride D2 dopamine receptors Neuropsychiatric disorders
DASP SERT receptors Neuropsychiatric disorders
Flumazenil Benzodiacepine receptor Neurodegenerative diseases
Methionine Amino acid transporter Brain, head and neck, lung and breast cancer, lymphomas
Choline Choline kinase Brain tumors, prostate, lung and esophageal cancer
Thymidine Thymidine kinase-1 Tumor proliferation
Palmitate Myocardinal tissue fatty acid metabolism Heart diseases

Specifications:

Total activity is dependent on the produced [11C]CO2, which means it is dependent on the selected cyclotron. Yields and specific activity of labeled [11C]tracers are dependent on use of proper technique and appropriate reagents.

Yields >50 % for [11C]CH3I in less than 7 min
Time for sequential synthesis Depends on the selected synthesis
Number of consecutive [11C]CH3I synthesis 15, then exchange of NaOH traps
Dimensions 55 x 45 x 48 cm (w x d x h)
Weight Approx. 45 Kg
Hot Cell (minimum size) 65 x 55 x 55 cm (w x d x h)