Production of carbon-11 labeled compounds based on C-11 methyl iodide or optional C-11 methyl triflate synthesis
A flexible and completely automated synthesis system for routine production of wide variety of carbon-11 labeled compounds based on the generation of gas-phase C-11 methyl iodide or optional C-11 methyl triflate.
The synthesis unit includes all components needed for preparation, labeling, purification and formulation of carbon-11 labeled compounds. Using in-target produced carbon dioxide, high specific activity preparations are produced ranging from 15 Ci/µmol to 50 Ci/µmol when high purity target gas is used for [11C]-CO2 production.
Examples for electrophilic [11C]compounds
|Raclopride||D2 dopamine receptors||Neuropsychiatric disorders|
|DASP||SERT receptors||Neuropsychiatric disorders|
|Flumazenil||Benzodiacepine receptor||Neurodegenerative diseases|
|Methionine||Amino acid transporter||Brain, head and neck, lung and breast cancer, lymphomas|
|Choline||Choline kinase||Brain tumors, prostate, lung and esophageal cancer|
|Thymidine||Thymidine kinase-1||Tumor proliferation|
|Palmitate||Myocardinal tissue fatty acid metabolism||Heart diseases|
Total activity is dependent on the produced [11C]CO2, which means it is dependent on the selected cyclotron. Yields and specific activity of labeled [11C]tracers are dependent on use of proper technique and appropriate reagents.
|Yields||>50 % for [11C]CH3I in less than 7 min|
|Time for sequential synthesis||Depends on the selected synthesis|
|Number of consecutive [11C]CH3I synthesis||15, then exchange of NaOH traps|
|Dimensions||55 x 45 x 48 cm (w x d x h)|
|Weight||Approx. 45 Kg|
|Hot Cell (minimum size)||65 x 55 x 55 cm (w x d x h)|