Production of 6-[18F]fluoro-L-Dopa and a variety of Fluorine-18
A flexible and completely automated synthesis system for routine production of 6-[18F]fluoro-L-Dopa and a variety of Fluorine-18 labelled compounds by electrophilic fluorination. The SynthraView configuration software offers both fully automatic and manual modes of operation of the Synthra F-Dopa module.
The target flow is controlled by a chemically inert flow controller. There are two synthesis reaction vessels allowing trapping of [18F]F2 target gas in separated reaction vessel for optimized reaction yields. Liquid transfer in performed with two build-in dispersers. The module includes a column for an in-process purification step, as well as a built in HPLC for separation. All wetted components are chemically inert, simplifying maintenance and protecting the final product.
Examples for electrophilic [18F] compounds
|F-Dopa||D2 dopamine receptors||Neurodegenerative diseases|
|Yield||20%, not decay corrected|
|Synthesis time||43 min|
|Dimensions||55 cm x 48 cm x 50 cm (w x d x h)|
|Weight||Approx. 45 Kg|
|Hot Cell (minimum size)||65 cm x 50 cm x 50 cm (w x d x h)|