Synthra Fusionplus

Synthra Fusionplus is a flexible and completely automated synthesis system for routine production of a wide variety of [¹¹C]carbon-labeled compounds based on the generation of gas-phase [¹¹C]methyl iodide or optional [11C]methyl triflate synthesis. The [¹¹C]methyl iodide can be used for solid support heterogeneous reactions for the synthesis of e. g. [¹¹C]choline and [¹¹C]methionine or can be released into the reaction vessel for homogeneous reactions. Additionally, this system is able to handle [¹⁸F]fluorine to perform syntheses of broad variety of [¹⁸F]-labeled compounds for routine production, such as [¹⁸F]FLT, [¹⁸F]FDG, [¹⁸F]TFB and many more. This is Synthra's most versatile synthesis module, combining the advantages of two different synthesizer families into one system.

Possibility to produce [¹¹C]- and [¹⁸F]-labeled tracers on one device
Simple creation of user-defined synthesis variations
C-11 gas phase chemistry (Yield >50% for [¹¹C]CH₃I in 7min)
Nine heating zones, six with cooling capabilities (-196 °C – 950 °C)
Two closed glassy carbon reaction vessels (-196 °C - 200 °C)
Three electronic flow controller for highly defined gas flow rates
Six shielded radiation detectors for in-process feedback
Built-in self-cleaning System
Built-in semi preparative Radio/UV-HPLC system (max. flow: 40 mL/min) with avariable wavelength detector (190 nm to 800 nm) and a quaternary gradient mixing chamber
Pneumatic column-switch valve for using two different HPLC columns
High resolution dispenser 0-24.000 steps, 5 mL syringe
Automatic pneumatic injection valve with a 1.5 to 5 mL sample loop

Number of consecutive [¹¹C]CH₃I synthesis	10, then exchange of NaOH trap is recommended
Dimensions	55 x 50 x 48 cm (w x d x h)
Weight	Approx. 41 Kg